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PAB30103 CDKN1B Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB30103
  • Application:    IHC,IF,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB30103 CDKN1B Polyclonal Antibody

320.00元

Catalog : PAB30103
Application : IHC,IF,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

CDKN1B Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

IHC,IF,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification



Immunogen Information



Immunogen

Recombinant protein of human CDKN1B

Calculated molecular weight

22kDa

Swiss Prot

P46527

Gene ID (NCBI)

1027

Alternative Names

CDKN4;KIP1;MEN1B;MEN4;P27KIP1



Application Notes


 

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

IHC

1:50 - 1:200

IF

1:20 - 1:50





  1                                                2

Immunohistochemistry of paraffin-embedded rat brain using CDKN1B Antibody.

 


Immunohistochemistry of paraffin-embedded mouse kidney using CDKN1B Antibody.

 


3
                                                 4

Immunohistochemistry of paraffin-embedded rat brain using CDKN1B Antibody.

 


Immunofluorescence analysis of HeLa cells using CDKN1B antibody.

 


Background



This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). 

 


Storage



Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.