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PAB35952 RNF34 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35952
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB35952 RNF34 Polyclonal Antibody

320.00元

Catalog : PAB35952
Application : WB,ELISA,IHC
Reactivity : Human
Product Information

 

Product name

RNF34 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human RNF34

Calculated molecular weight

41kDa

Observed molecular weight 

42kDa

Swiss Prot

Q969K3

Gene ID (NCBI)

80196

Alternative Names

CARP-1;CARP1;hRFI;RFI;RIF;RIFF


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using RNF34 antibody.    


Background


The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.