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PAB35945 TMEM43 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35945
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse

库存 800 件

PAB35945 TMEM43 Polyclonal Antibody

320.00元

Catalog : PAB35945
Application : WB,IHC,ELISA
Reactivity : Human,Mouse
Product Information

 

Product name

TMEM43 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human TMEM43

Calculated molecular weight

44kDa

Observed molecular weight 

45kDa

Swiss Prot

Q9BTV4

Gene ID (NCBI)

79188

Alternative Names

ARVC5;ARVD5;EDMD7;LUMA


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:100

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Western blot analysis of extracts of various cell lines, using TMEM43 antibody.


Immunohistochemistry of paraffin-embedded human stomach using TMEM43 antibody.


Background


This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.