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PAB34928 PSMD13 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB34928
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB34928 PSMD13 Polyclonal Antibody

320.00元

Catalog : PAB34928
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

PSMD13 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human PSMD13

Calculated molecular weight

42kDa

Observed molecular weight 

43kDa

Swiss Prot

Q9UNM6

Gene ID (NCBI)

5719

Alternative Names

HSPC027;p40.5;Rpn9;S11


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

 

    1                       

Western blot analysis of extracts of various cell lines, using PSMD13 antibody.

                    

2                           3  

Immunohistochemistry of paraffin-embedded human liver injury using PSMD13 antibody.


Immunohistochemistry of paraffin-embedded mouse lung using PSMD13 antibody.


Background

        

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.  An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described.                                                                                   

                                                                                         

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.