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PAB33671 TGFB2 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB33671
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB33671 TGFB2 Polyclonal Antibody

320.00元

Catalog : PAB33671
Application : WB,ELISA,IHC
Reactivity : Human,Mouse
Product Information


Product name

TGFB2 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human TGFB2

Calculated molecular weight

47kDa/50kDa

Observed molecular weight 

55kDa

Swiss Prot

P61812

Gene ID (NCBI)

7042

Alternative Names

LDS4;TGF-beta2


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:200 - 1:2000

IHC

1:50 - 1:500

           blob.png

Western blot analysis of extracts of various cell lines, using TGFB2 antibody.


Background

  

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.   

                                                                          

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.