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PAB34925 PRKAB2 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB34925
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB34925 PRKAB2 Polyclonal Antibody

320.00元

Catalog : PAB34925
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

PRKAB2 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification

 

Immunogen Information


Immunogen

Recombinant protein of human PRKAB2

Calculated molecular weight

21kDa/30kDa

Observed molecular weight 

35kDa

Swiss Prot

O43741

Gene ID (NCBI)

5565

Alternative Names

AMPK beta 2, AMPK subunit beta 2, PRKAB2


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

 

 1                2                    

Western blot analysis of extracts of various cell lines, using PRKAB2 antibody.


Immunohistochemistry of paraffin-embedded rat kidney using PRKAB2 antibody.

 

Background


    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene                                                                                             


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.