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PAB36310-P Phospho-RB-S795 pAb

价格:    580.00元

  • Catalog:    PAB36310-P
  • Application:    WB,IF,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB36310-P Phospho-RB-S795 pAb

580.00元

Catalog : PAB36310-P
Application : WB,IF,ELISA,IHC
Reactivity : Human
Product Information

 

Product name

Phospho-RB-S795 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IF,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding S795 of human RB

Calculated molecular weight

106kDa

Observed molecular weight 

106kDa

Swiss Prot

P06400

Gene ID (NCBI)

5925

Alternative Names

OSRC;p105-Rb;pp110;PPP1R130;pRb;RB


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:1000

IF

1:50 - 1:100

IHC

1:50 - 1:500

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Western blot analysis of extracts of 293 cell line, using phospho-RB-S795 antibody.


Immunofluorescence analysis of U2OS cells using Phospho-RB-S795 antibody.

 

Background


The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.  


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.