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PAB36307-P Phospho-p53-S9 pAb

价格:    580.00元

  • Catalog:    PAB36307-P
  • Application:    WB,IF,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB36307-P Phospho-p53-S9 pAb

580.00元

Catalog : PAB36307-P
Application : WB,IF,ELISA,IHC
Reactivity : Human
Product Information

 

Product name

Phospho-p53-S9 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IF,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding S9 of human P53

Calculated molecular weight

23-43kDa

Observed molecular weight 

55kDa

Swiss Prot

P04637

Gene ID (NCBI)

7157

Alternative Names

BCC7;LFS1;P53;TRP53


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IF

1:50 - 1:200

IHC

1:50 - 1:500

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Western blot analysis of extracts of 293 and HT-29 cells, using Phospho-p53-S9 antibody.


Immunofluorescence analysis of U2OS cells using Phospho-p53-S9 antibody.


Background


This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).  


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.