Lyophilized or Liquid
A phospho specific peptide corresponding to residues surrounding S166 of human MDM2
Calculated molecular weight
Observed molecular weight
Gene ID (NCBI)
1:500 - 1:1000
1:50 - 1:100
1:50 - 1:500
Western blot analysis of extracts of 293 cells, using Phospho-MDM2-S166 antibody.
Immunofluorescence analysis of U2OS cells using Phospho-MDM2-S166 antibody.
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.