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PAB36303-P Phospho-MAP3K7-S412 pAb

价格:    580.00元

  • Catalog:    PAB36303-P
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB36303-P Phospho-MAP3K7-S412 pAb

580.00元

Catalog : PAB36303-P
Application : WB,ELISA,IHC
Reactivity : Human
Product Information

 

Product name

Phospho-MAP3K7-S412 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding S412 of human MAP3K7

Calculated molecular weight

53kDa/56kDa/64kDa/67kDa

Observed molecular weight 

67kDa

Swiss Prot

O43318

Gene ID (NCBI)

6885

Alternative Names

CSCF;FMD2;MEKK7;TAK1;TGF1a;MEKK7;TAK1;TGF1a


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

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Western blot analysis of extracts of K-562 cells, using Phospho-MAP3K7-S412 antibody.


Background


The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.  


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.