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PAB35597 TNNI2 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35597
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35597 TNNI2 Polyclonal Antibody

320.00元

Catalog : PAB35597
Application : WB,ELISA,IHC
Reactivity : Human,Mouse,Rat
Product Information


Product name

TNNI2 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human TNNI2

Calculated molecular weight

21kDa

Observed molecular weight 

21kDa

Swiss Prot

P48788

Gene ID (NCBI)

7136

Alternative Names

AMCD2B;DA2B;FSSV;fsTnI


Application Notes


The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

 

         1                  

Western blot analysis of extracts of various cell lines, using TNNI2 antibody.

     

Background


This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.   

                                                                                                 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.