Lyophilized or Liquid
A synthetic phosphorylated peptide around Y705 of human Stat3
Calculated molecular weight
Observed molecular weight
Gene ID (NCBI)
1:500 - 1:2000
1:50 - 1:200
1:50 - 1:200
Western blot analysis of extracts of HeLa cells, using Phospho-Stat3-Y705 antibody.
Immunohistochemistry of paraffin-embedded rat ovary using P-STAT3-Y705 antibody.
Immunohistochemistry of paraffin-embedded human appendix using P-STAT3-Y705 antibody.
Immunohistochemistry of paraffin-embedded human breast using P-STAT3-Y705 antibody.
Immunohistochemistry of paraffin-embedded mouse liver using P-STAT3-Y705 antibody.
Immunofluorescence analysis of U2OS cells using Phospho-Stat3-Y705 antibody.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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