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PAB36302-P Phospho-Stat3-Y705 pAb

价格:    580.00元

  • Catalog:    PAB36302-P
  • Application:    WB,IHC,IF,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB36302-P Phospho-Stat3-Y705 pAb

580.00元

Catalog : PAB36302-P
Application : WB,IHC,IF,ELISA
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

Phospho-Stat3-Y705 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,IF,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification



Immunogen Information


Immunogen

A synthetic phosphorylated peptide around Y705 of human Stat3

Calculated molecular weight

83kDa/87kDa/88kDa

Observed molecular weight 

105kDa

Swiss Prot

P40763

Gene ID (NCBI)

6774

Alternative Names

ADMIO;ADMIO1;APRF;HIES;ADMIO;APRF;HIES


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

IF

1:50 - 1:200

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Western blot analysis of extracts of HeLa cells, using Phospho-Stat3-Y705 antibody.


Immunohistochemistry of paraffin-embedded rat ovary using P-STAT3-Y705 antibody.

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Immunohistochemistry of paraffin-embedded human appendix using P-STAT3-Y705 antibody.


Immunohistochemistry of paraffin-embedded human breast using P-STAT3-Y705 antibody.

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Immunohistochemistry of paraffin-embedded mouse liver using P-STAT3-Y705 antibody.


Immunofluorescence analysis of U2OS cells using Phospho-Stat3-Y705 antibody.



Background



The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.  



Storage



Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.