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PAB36196 CAPN10 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36196
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB36196 CAPN10 Polyclonal Antibody

320.00元

Catalog : PAB36196
Application : WB,ELISA,IHC
Reactivity : Human
Product Information

 

Product name

CAPN10 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human CAPN10

Calculated molecular weight

15kDa/29kDa/49kDa/57kDa/60kDa/74kDa

Observed molecular weight 

75kDa

Swiss Prot

Q9HC96

Gene ID (NCBI)

11132

Alternative Names

CANP10;NIDDM1


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:1000 - 1:4000

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using CAPN10 antibody.


Background


Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.