Product name | SAFB Polyclonal Antibody |
Isotype | IgG |
Form | Lyophilized or Liquid |
Tested applications | WB,IHC,ELISA |
Species reactivity | Human,Mouse,Rat |
Host Species | Rabbit |
Purity | Affinity purification |
Immunogen Recombinant protein of human SAFB Calculated molecular weight 95kDa/102kDa Observed molecular weight 130kDa Swiss Prot Q15424 Gene ID (NCBI) 6294 Alternative Names HAP;HET;SAB-B1;SAF-B;SAF-B1;SAFB1 The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. WB 1:500 - 1:2000 IHC 1:50 - 1:200 Western blot analysis of extracts of various cell lines, using SAFB antibody. Immunohistochemistry of paraffin-embedded rat lung using SAFB antibody. Immunohistochemistry of paraffin-embedded rat liver using SAFB antibody. Immunohistochemistry of paraffin-embedded rat testis using SAFB antibody. Immunohistochemistry of paraffin-embedded rat brain using SAFB antibody. Immunohistochemistry of paraffin-embedded rat spleen using SAFB antibody. Immunohistochemistry of paraffin-embedded rat kidney using SAFB antibody. Immunohistochemistry of paraffin-embedded rat heart using SAFB antibody. Immunohistochemistry of paraffin-embedded human liver cancer using SAFB antibody. Immunohistochemistry of paraffin-embedded human breast cancer using SAFB antibody. Immunohistochemistry of paraffin-embedded human gastric cancer using SAFB antibody. Immunohistochemistry of paraffin-embedded mouse liver using SAFB antibody. Immunohistochemistry of paraffin-embedded mouse brain using SAFB antibody. Immunohistochemistry of paraffin-embedded mouse kidney using SAFB antibody. Immunohistochemistry of paraffin-embedded mouse heart using SAFB antibody. 
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
