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PAB35592 SAFB Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35592
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35592 SAFB Polyclonal Antibody

320.00元

Catalog : PAB35592
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

SAFB Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human SAFB

Calculated molecular weight

95kDa/102kDa

Observed molecular weight 

130kDa

Swiss Prot

Q15424

Gene ID (NCBI)

6294

Alternative Names

HAP;HET;SAB-B1;SAF-B;SAF-B1;SAFB1


Application Notes


The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

 

1    2   3              

Western blot analysis of extracts of various cell lines, using SAFB antibody.

Immunohistochemistry of paraffin-embedded rat lung using SAFB antibody.

Immunohistochemistry of paraffin-embedded rat liver using SAFB antibody.

                

4    5    6

Immunohistochemistry of paraffin-embedded rat testis using SAFB antibody.

Immunohistochemistry of paraffin-embedded rat brain using SAFB antibody.

Immunohistochemistry of paraffin-embedded rat spleen using SAFB antibody.

7   8     9

Immunohistochemistry of paraffin-embedded rat kidney using SAFB antibody.

Immunohistochemistry of paraffin-embedded rat heart using SAFB antibody.

Immunohistochemistry of paraffin-embedded human liver cancer using SAFB antibody.

10 11  12

Immunohistochemistry of paraffin-embedded human breast cancer using SAFB antibody.

Immunohistochemistry of paraffin-embedded human gastric cancer using SAFB antibody.

Immunohistochemistry of paraffin-embedded mouse liver using SAFB antibody.

13 14  15

Immunohistochemistry of paraffin-embedded mouse brain using SAFB antibody.

Immunohistochemistry of paraffin-embedded mouse kidney using SAFB antibody.

Immunohistochemistry of paraffin-embedded mouse heart using SAFB antibody.

     

Background

 

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.     

                                                                                                

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.