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PAB34919 PLOD2 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB34919
  • Application:    WB,IF,ELISA,IHC
  • Reactivity:    Human,Rat

库存 800 件

PAB34919 PLOD2 Polyclonal Antibody

320.00元

Catalog : PAB34919
Application : WB,IF,ELISA,IHC
Reactivity : Human,Rat
Product Information


Product name

PLOD2 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IF,ELISA,IHC

Species reactivity

Human,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human PLOD2

Calculated molecular weight

49kDa/84kDa/87kDa

Observed molecular weight 

84kDa

Swiss Prot

O00469

Gene ID (NCBI)

5352

Alternative Names

BRKS2;LH2;TLH

 

Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IF

1:50 - 1:100

IHC

1:50 - 1:500

     1                          2          

Western blot analysis of extracts of rat kidney, using PLOD2 Antibody.


Immunofluorescence analysis of U2OS cells using PLOD2 antibody.

 

Background

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. 

                                                                                                 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.