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PAB34917 PDE6B Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB34917
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB34917 PDE6B Polyclonal Antibody

320.00元

Catalog : PAB34917
Application : WB,ELISA,IHC
Reactivity : Human,Mouse,Rat
Product Information


Product name

PDE6B Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human PDE6B

Calculated molecular weight

66kDa/98kDa

Observed molecular weight 

98kDa

Swiss Prot

P35913

Gene ID (NCBI)

5158

Alternative Names

CSNB3;CSNBAD2;GMP-PDEbeta;PDEB;rd1;RP40;CSNB3;CSNBAD2;PDEB;rd1;RP40


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

 

       1                    

Western blot analysis of extracts of various cell lines, using PDE6B antibody.

                 

Background


Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.                                                                                            

                                                                                                 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.