欢迎来到Bioswamp武汉贝茵莱生物科技有限公司   注册   登录

PAB34916 PARN Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB34916
  • Application:    WB,IF,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB34916 PARN Polyclonal Antibody

320.00元

Catalog : PAB34916
Application : WB,IF,ELISA,IHC
Reactivity : Human
Product Information


Product name

PARN Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IF,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification

 

Immunogen Information


Immunogen

Recombinant protein of human PARN

Calculated molecular weight

52kDa/66kDa/67kDa/73kDa

Observed molecular weight 

73kDa

Swiss Prot

O95453

Gene ID (NCBI)

5073

Alternative Names

DAN;DKCB6;PFBMFT4


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IF

1:50 - 1:100

IHC

1:50 - 1:500

  1             2                  

Western blot analysis of extracts of various cell lines, using PARN antibody.


Immunofluorescence analysis of MCF7 cells using PARN antibody.

                   

Background


The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 

                                                                                                 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.