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PAB36286-PPhospho-ERBB4-Y1284 pAb

价格:    580.00元

  • Catalog:    PAB36286-P
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB36286-PPhospho-ERBB4-Y1284 pAb

580.00元

Catalog : PAB36286-P
Application : WB,ELISA,IHC
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

Phospho-ERBB4-Y1284 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification



Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding Y1284 of human HER4

Calculated molecular weight

143kDa/145kDa/146kDa

Observed molecular weight 

200kDa

Swiss Prot

Q15303

Gene ID (NCBI)

2066

Alternative Names

ALS19;HER4;p180erbB4


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

          blob.png

Western blot analysis of extracts of A-431 cells, using Phospho-ERBB4-Y1284 antibody.




Background



This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.  



Storage



Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.