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PAB35671 ARNT2 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35671
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35671 ARNT2 Polyclonal Antibody

320.00元

Catalog : PAB35671
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

ARNT2 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human ARNT2

Calculated molecular weight

77kDa/78kDa

Observed molecular weight 

79kDa

Swiss Prot

Q9HBZ2

Gene ID (NCBI)

9915

Alternative Names

bHLHe1;WEDAS


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

 

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Western blot analysis of extracts of various cell lines, using ARNT2 antibody.


Immunohistochemistry of paraffin-embedded human kidney using ARNT2 antibody.


Background

  

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.      

                                                                          

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.