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PAB36163 TIMM8A Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36163
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB36163 TIMM8A Polyclonal Antibody

320.00元

Catalog : PAB36163
Application : WB,ELISA,IHC
Reactivity : Human,Mouse
Product Information

 

Product name

TIMM8A Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification

 

Immunogen Information


Immunogen

Recombinant protein of human TIMM8A

Calculated molecular weight

10kDa

Observed molecular weight 

11kDa

Swiss Prot

O60220

Gene ID (NCBI)

1678

Alternative Names

DDP;DDP1;DFN1;MTS;TIM8


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500



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Western blot analysis of extracts of various cell lines, using TIMM8A antibody.


Background


This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.