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PAB36285-P Phospho-EIF4EBP1-T70 pAb

价格:    580.00元

  • Catalog:    PAB36285-P
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB36285-P Phospho-EIF4EBP1-T70 pAb

580.00元

Catalog : PAB36285-P
Application : WB,ELISA,IHC
Reactivity : Human,Mouse,Rat
Product Information

Product name

Phospho-EIF4EBP1-T70 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding T70 of human EIF4EBP1

Calculated molecular weight

12kDa

Observed molecular weight 

20kDa

Swiss Prot

Q13541

Gene ID (NCBI)

1978

Alternative Names

4E-BP1;4EBP1;BP-1;PHAS-I



Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

            blob.png

Western blot analysis of extracts of 293 cells, using Phospho-EIF4EBP1-T70 antibody.



Background

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.   


Storage

Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.



1、

文献链接:https://www.frontiersin.org/articles/10.3389/fmolb.2021.645365/full

文献题目:Long Non-coding RNA DLEU2L Targets miR-210-3p to Suppress Gemcitabine Resistance in Pancreatic Cancer Cells via BRCA2 Regulation

发表期刊:Frontiers in Molecular Biosciences

影响因子:5.246

DOI10.3389/fmolb.2021.645365

出版信息:Front Mol Biosci. 2021 Apr;0:296