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PAB36278-P Phospho-ATF2-T71 pAb

价格:    580.00元

  • Catalog:    PAB36278-P
  • Application:    WB,IF,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB36278-P Phospho-ATF2-T71 pAb

580.00元

Catalog : PAB36278-P
Application : WB,IF,ELISA,IHC
Reactivity : Human,Mouse
Product Information

 

Product name

Phospho-ATF2-T71 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IF,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding T71 of human ATF2

Calculated molecular weight

13- 15kDa/23-24kDa/35-54kDa

Observed molecular weight 

70kDa

Swiss Prot

P15336

Gene ID (NCBI)

1386

Alternative Names

HB16; CREB2; TREB7; CREB-2; CRE-BP1


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:1000

IF

1:50 - 1:100

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using Phospho-ATF2-T71 antibody.


Immunofluorescence analysis of MCF-7 cells using Phospho-ATF2-T71 antibody.


Background


This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene   


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.