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PAB36146 PHOX2B Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36146
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB36146 PHOX2B Polyclonal Antibody

320.00元

Catalog : PAB36146
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

PHOX2B Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human PHOX2B

Calculated molecular weight

31kDa

Observed molecular weight 

32kDa

Swiss Prot

Q99453

Gene ID (NCBI)

8929

Alternative Names

NBLST2;NBPhox;PMX2B


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

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 Western blot analysis of extracts of various cell lines, using PHOX2B antibody.      

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Immunohistochemistry of paraffin-embedded rat liver using PHOX2B antibody.


Immunohistochemistry of paraffin-embedded rat kidney using PHOX2B antibody.


Background


The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.