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PAB36274-P Phospho-BRAF-S445 pAb

价格:    580.00元

  • Catalog:    PAB36274-P
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB36274-P Phospho-BRAF-S445 pAb

580.00元

Catalog : PAB36274-P
Application : WB,ELISA,IHC
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

Phospho-BRAF-S445 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding S445 of human BRAF

Calculated molecular weight

84kDa

Observed molecular weight 

95kDa

Swiss Prot

P15056

Gene ID (NCBI)

673

Alternative Names

B-raf;B-RAF1;BRAF1;NS7;RAFB1;B-RAF1;BRAF1;NS7;RAFB1


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

               blob.png

Western blot analysis of extracts of Raji cells, using Phospho-BRAF-S445 antibody.


Background


This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.