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PAB35569 FLNA Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35569
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35569 FLNA Polyclonal Antibody

320.00元

Catalog : PAB35569
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

FLNA Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A synthetic peptide of human FLNA

Calculated molecular weight

280kDa

Observed molecular weight 

281kDa

Swiss Prot

P21333

Gene ID (NCBI)

2316

Alternative Names

ABP-280;ABPX;CSBS;CVD1;FLN;FLN-A;FLN1;FMD;MNS;NHBP;OPD;OPD1;OPD2;XLVD;XMVD


Application Notes


The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

 

    1                         2 

Western blot analysis of extracts of various cell lines, using FLNA antibody.


Immunohistochemistry of paraffin-embedded human oophoroma using FLNA antibody.

     

Background


The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.          

                                                                                                 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.