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PAB36273-P Phospho-FAS-Y291 pAb

价格:    580.00元

  • Catalog:    PAB36273-P
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB36273-P Phospho-FAS-Y291 pAb

580.00元

Catalog : PAB36273-P
Application : WB,ELISA,IHC
Reactivity : Human
Product Information

 

Product name

Phospho-FAS-Y291 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding Y291 of human FAS

Calculated molecular weight

9kDa/11kDa/14kDa/16kDa/24kDa/35kDa/37kDa

Observed molecular weight 

55kDa

Swiss Prot

P25445

Gene ID (NCBI)

355

Alternative Names

ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

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Western blot analysis of extracts of 293 and HeLa cells, using Phospho-FAS-Y291 antibody.



Background


The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.   


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.