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PAB36272-P Phospho-APP-T668 pAb

价格:    580.00元

  • Catalog:    PAB36272-P
  • Application:    WB
  • Reactivity:    Mouse,Rat

库存 800 件

PAB36272-P Phospho-APP-T668 pAb

580.00元

Catalog : PAB36272-P
Application : WB
Reactivity : Mouse,Rat
Product Information

 

Product name

Phospho-APP-T668 pAb

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB

Species reactivity

Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A phospho specific peptide corresponding to residues surrounding T668 of human APP

Calculated molecular weight

34kDa/72-86kDa

Observed molecular weight 

87kDa, 120kDa

Swiss Prot

P05067

Gene ID (NCBI)

351

Alternative Names

AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2;preA4


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000



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Western blot analysis of extracts of various cell lines, using Phospho-APP-T668 antibody.


Background


This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.  


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.