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PAB35557 CBL Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35557
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35557 CBL Polyclonal Antibody

320.00元

Catalog : PAB35557
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

CBL Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A synthetic peptide of human CBL

Calculated molecular weight

99kDa

Observed molecular weight 

120kDa

Swiss Prot

P22681

Gene ID (NCBI)

867

Alternative Names

C-CBL;CBL2;FRA11B;NSLL;RNF55


Application Notes


The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:100

 

1                 2                     

Western blot analysis of extracts of various cell lines, using CBL antibody.


Immunohistochemistry of paraffin-embedded mouse stomach using CBL antibody.

 

3                4                

Immunohistochemistry of paraffin-embedded rat kidney using CBL antibody.


Immunohistochemistry of paraffin-embedded mouse liver using CBL antibody.

     

Background


This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.                                                                                                        

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.