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PAB35555 AVPR2 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35555
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Monkey

库存 800 件

PAB35555 AVPR2 Polyclonal Antibody

320.00元

Catalog : PAB35555
Application : WB,ELISA,IHC
Reactivity : Human,Monkey
Product Information


Product name

AVPR2 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Monkey

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human AVPR2

Calculated molecular weight

33kDa/40kDa

Observed molecular weight 

46kDa

Swiss Prot

P30518

Gene ID (NCBI)

554

Alternative Names

ADHR;DI1;DIR;DIR3;NDI;V2R


Application Notes


 

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

 

               1            

Western blot analysis of extracts of various cell lines, using AVPR2 Antibody.

    

Background


This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.      

                                                                                                 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.