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PAB35931 ARHGEF3 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35931
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse

库存 800 件

PAB35931 ARHGEF3 Polyclonal Antibody

320.00元

Catalog : PAB35931
Application : WB,IHC,ELISA
Reactivity : Human,Mouse
Product Information


Product name

ARHGEF3 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human ARHGEF3

Calculated molecular weight

36kDa/59kDa/60kDa/63kDa

Observed molecular weight 

60kDa

Swiss Prot

Q9NR81

Gene ID (NCBI)

50650

Alternative Names

GEF3;STA3;XPLN


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

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Western blot analysis of extracts of various cell lines, using ARHGEF3 antibody.


Immunohistochemistry of paraffin-embedded mouse brain using ARHGEF3 antibody.


Background

   

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

                                                                                              

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.