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PAB35546 ACVR2B Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35546
  • Application:    WB,IF,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB35546 ACVR2B Polyclonal Antibody

320.00元

Catalog : PAB35546
Application : WB,IF,ELISA,IHC
Reactivity : Human
Product Information


Product name

ACVR2B Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IF,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A synthetic peptide of human ACVR2B

Calculated molecular weight

57kDa

Observed molecular weight 

58kDa

Swiss Prot

Q13705

Gene ID (NCBI)

93

Alternative Names

ActR-IIB;ACTRIIB;HTX4


Application Notes


The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IF

1:50 - 1:200

IHC

1:50 - 1:500

 

                  1         

Western blot analysis of extracts of various cell lines, using ACVR2B antibody.

     

Background


Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.                                                                                                    


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.