Product name | PCSK9 Polyclonal Antibody |
Isotype | IgG |
Form | Lyophilized or Liquid |
Tested applications | WB,IHC,ELISA |
Species reactivity | Human,Mouse,Rat |
Host Species | Rabbit |
Purity | Affinity purification |
Immunogen | A synthetic peptide of human PCSK9 |
Calculated molecular weight | 20kDa/74kDa |
Observed molecular weight | 60kDa, 72kDa |
Swiss Prot | Q8NBP7 |
Gene ID (NCBI) | 255738 |
Alternative Names | FH3;HCHOLA3;LDLCQ1;NARC-1;NARC1;PC9 |
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB | 1:500 - 1:2000 |
IHC | 1:50 - 1:200 |
Western blot analysis of extracts of SW480 cells, using PCSK9 Antibody. | Immunohistochemistry of paraffin-embedded rat kidney using PCSK9 antibody. |
Immunohistochemistry of paraffin-embedded human stomach using PCSK9 antibody. | Immunohistochemistry of paraffin-embedded mouse liver using PCSK9 antibody. |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |