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PAB35541 PCSK9 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35541
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35541 PCSK9 Polyclonal Antibody

320.00元

Catalog : PAB35541
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

PCSK9 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

A synthetic peptide of human PCSK9

Calculated molecular weight

20kDa/74kDa

Observed molecular weight 

60kDa, 72kDa

Swiss Prot

Q8NBP7

Gene ID (NCBI)

255738

Alternative Names

FH3;HCHOLA3;LDLCQ1;NARC-1;NARC1;PC9


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

 

       图片关键词                             图片关键词    

Western blot analysis of extracts of SW480 cells, using PCSK9 Antibody.


Immunohistochemistry of paraffin-embedded rat kidney using PCSK9 antibody.

 

    图片关键词                          图片关键词         

Immunohistochemistry of paraffin-embedded human stomach using PCSK9 antibody.


Immunohistochemistry of paraffin-embedded mouse liver using PCSK9 antibody.


Background


This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

                                                                                               


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.