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PAB36253 NSD1 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36253
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB36253 NSD1 Polyclonal Antibody

320.00元

Catalog : PAB36253
Application : WB,ELISA,IHC
Reactivity : Human,Mouse
Product Information

 

Product name

NSD1 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human NSD1

Calculated molecular weight

267kDa/284kDa/296kDa

Observed molecular weight 

297kDa

Swiss Prot

Q96L73

Gene ID (NCBI)

64324

Alternative Names

ARA267;KMT3B;SOTOS;SOTOS1;STO


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:1000

IHC

1:50 - 1:500

   blob.png

Western blot analysis of extracts of various cell lines, using NSD1 antibody.


Background


This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.  


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.