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PAB36252 SAV1 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36252
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB36252 SAV1 Polyclonal Antibody

320.00元

Catalog : PAB36252
Application : WB,ELISA,IHC
Reactivity : Human
Product Information

 

Product name

SAV1 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human SAV1

Calculated molecular weight

44kDa

Observed molecular weight 

45kDa

Swiss Prot

Q9H4B6

Gene ID (NCBI)

60485

Alternative Names

SAV;WW45;WWP4


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:1000 - 1:4000

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using SAV1 antibody.


Background


WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.