欢迎来到Bioswamp武汉贝茵莱生物科技有限公司   注册   登录

PAB35917 ABCB11 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35917
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB35917 ABCB11 Polyclonal Antibody

320.00元

Catalog : PAB35917
Application : WB,ELISA,IHC
Reactivity : Human,Mouse
Product Information


Product name

ABCB11 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human ABCB11

Calculated molecular weight

146kDa

Observed molecular weight 

170kDa

Swiss Prot

O95342

Gene ID (NCBI)

8647

Alternative Names

ABC16;BRIC2;BSEP;PFIC-2;PFIC2;PGY4;SPGP


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

        blob.png                        

Western blot analysis of extracts of various cell lines, using ABCB11 antibody.


Background

   

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.  

                                                                                              

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.