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PAB35913 HIRA Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35913
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse

库存 800 件

PAB35913 HIRA Polyclonal Antibody

320.00元

Catalog : PAB35913
Application : WB,IHC,ELISA
Reactivity : Human,Mouse
Product Information


Product name

HIRA Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human HIRA

Calculated molecular weight

89kDa/111kDa

Observed molecular weight 

112kDa

Swiss Prot

P54198

Gene ID (NCBI)

7290

Alternative Names

DGCR1;TUP1;TUPLE1


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:100 - 1:200

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Western blot analysis of extracts of various cell lines, using HIRA antibody.


Immunohistochemistry of paraffin-embedded human gastric cancer using HIRA antibody.

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Immunohistochemistry of paraffin-embedded human lung cancer using HIRA antibody.


Immunohistochemistry of paraffin-embedded human colon carcinoma using HIRA antibody.


Background

   

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.  

                                                                                             

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.