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PAB35905 PER1 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35905
  • Application:    WB,IHC,IF,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35905 PER1 Polyclonal Antibody

320.00元

Catalog : PAB35905
Application : WB,IHC,IF,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

PER1 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,IF,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human PER1

Calculated molecular weight

91kDa/136kDa

Observed molecular weight 

160kDa

Swiss Prot

O15534

Gene ID (NCBI)

5187

Alternative Names

hPER;PER;RIGUI


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:100

IF

1:50 - 1:200

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Western blot analysis of extracts of various cell lines, using PER1 antibody.


Immunohistochemistry of paraffin-embedded human stomach using PER1 antibody.

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Immunohistochemistry of paraffin-embedded rat kidney using PER1 antibody.

Immunohistochemistry of paraffin-embedded mouse stomach using PER1 antibody.

Immunofluorescence analysis of U2OS cells using PER1 antibody.


Background

   

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.  

                                                                                             

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.