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PAB36089 SNX15 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36089
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB36089 SNX15 Polyclonal Antibody

320.00元

Catalog : PAB36089
Application : WB,ELISA,IHC
Reactivity : Human,Mouse
Product Information

 

Product name

SNX15 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human SNX15

Calculated molecular weight

29kDa/38kDa

Observed molecular weight 

50kDa

Swiss Prot

Q9NRS6

Gene ID (NCBI)

29907

Alternative Names

HSAF001435


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500



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Western blot analysis of extracts of various cell lines, using SNX15 antibody.


Background


This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.