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PAB36070 GCDH Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36070
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB36070 GCDH Polyclonal Antibody

320.00元

Catalog : PAB36070
Application : WB,ELISA,IHC
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

GCDH Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human GCDH

Calculated molecular weight

47kDa/48kDa

Observed molecular weight 

48kDa

Swiss Prot

Q92947

Gene ID (NCBI)

2639

Alternative Names

ACAD5;GCD


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:200 - 1:2000

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using GCDH antibody.                           

 

Background


The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.