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PAB36063 RPSA Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36063
  • Application:    WB,ELISA,IHC
  • Reactivity:    Mouse

库存 800 件

PAB36063 RPSA Polyclonal Antibody

320.00元

Catalog : PAB36063
Application : WB,ELISA,IHC
Reactivity : Mouse
Product Information

 

Product name

RPSA Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human RPSA

Calculated molecular weight

32kDa

Observed molecular weight 

38kDa

Swiss Prot

P08865

Gene ID (NCBI)

3921

Alternative Names

37LRP;67LR;ICAS;LAMBR;lamR;LAMR1;LBP;LBP/p40;LRP;LRP/LR;NEM/1CHD4;p40;SA


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using RPSA antibody.


Background


Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.   


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.