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PAB36062 SIRPA Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36062
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB36062 SIRPA Polyclonal Antibody

320.00元

Catalog : PAB36062
Application : WB,ELISA,IHC
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

SIRPA Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human SIRPA

Calculated molecular weight

54kDa/55kDa

Observed molecular weight 

120kDa

Swiss Prot

P78324

Gene ID (NCBI)

140885

Alternative Names

BIT;CD172A;MFR;MYD-1;P84;PTPNS1;SHPS1;SIRP


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:200 - 1:2000

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using SIRPA antibody.                           

 


Background


The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. 

 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.