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PAB36055 SPAG8 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36055
  • Application:    WB,ELISA,IHC
  • Reactivity:    Mouse,Rat

库存 800 件

PAB36055 SPAG8 Polyclonal Antibody

320.00元

Catalog : PAB36055
Application : WB,ELISA,IHC
Reactivity : Mouse,Rat
Product Information

 

Product name

SPAG8 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human SPAG8

Calculated molecular weight

44kDa/51kDa/53kDa

Observed molecular weight 

45kDa

Swiss Prot

Q99932

Gene ID (NCBI)

26206

Alternative Names

BS-84;CILD28;CT142;HSD-1;hSMP-1;SMP1;SPAG3


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500



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Western blot analysis of extracts of various cell lines, using SPAG8 antibody.

 


Background


The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. 

 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.