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PAB36046 BBS10 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36046
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB36046 BBS10 Polyclonal Antibody

320.00元

Catalog : PAB36046
Application : WB,ELISA,IHC
Reactivity : Human,Mouse
Product Information

 

Product name

BBS10 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human BBS10

Calculated molecular weight

80kDa

Observed molecular weight 

81kDa

Swiss Prot

Q8TAM1

Gene ID (NCBI)

79738

Alternative Names

C12orf58


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:200 - 1:3000

IHC

1:50 - 1:500



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Western blot analysis of extracts of various cell lines, using BBS10 antibody.


Background


This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.