欢迎来到Bioswamp武汉贝茵莱生物科技有限公司   注册   登录

PAB35529 CHRFAM7A Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35529
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35529 CHRFAM7A Polyclonal Antibody

320.00元

Catalog : PAB35529
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

CHRFAM7A Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human CHRFAM7A

Calculated molecular weight

46kDa

Observed molecular weight 

46kDa

Swiss Prot

Q494W8

Gene ID (NCBI)

89832

Alternative Names

CHRNA7;CHRNA7-DR1;D-10


Application Notes


 

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

WB 1:500 - 1:2000

IHC

1:50 - 1:200

IHC 1:50 - 1:200

 

    1                       

Western blot analysis of extracts of various cell lines, using CHRFAM7A antibody.

 

                  

2    3    4

Immunohistochemistry of paraffin-embedded rat brain using CHRFAM7A antibody.

Immunohistochemistry of paraffin-embedded rat kidney using CHRFAM7A antibody.

Immunohistochemistry of paraffin-embedded human prostate using CHRFAM7A antibody.

5    6    7

Immunohistochemistry of paraffin-embedded human stomach using CHRFAM7A antibody.

Immunohistochemistry of paraffin-embedded mouse brain using CHRFAM7A antibody.

Immunohistochemistry of paraffin-embedded mouse stomach using CHRFAM7A antibody.

    

Background


     The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.                                                                                             


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.