Product name | CHRFAM7A Polyclonal Antibody |
Isotype | IgG |
Form | Lyophilized or Liquid |
Tested applications | WB,IHC,ELISA |
Species reactivity | Human,Mouse,Rat |
Host Species | Rabbit |
Purity | Affinity purification |
Immunogen Recombinant protein of human CHRFAM7A Calculated molecular weight 46kDa Observed molecular weight 46kDa Swiss Prot Q494W8 Gene ID (NCBI) 89832 Alternative Names CHRNA7;CHRNA7-DR1;D-10 The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. WB 1:500 - 1:2000 WB 1:500 - 1:2000 IHC 1:50 - 1:200 IHC 1:50 - 1:200 Western blot analysis of extracts of various cell lines, using CHRFAM7A antibody. Immunohistochemistry of paraffin-embedded rat brain using CHRFAM7A antibody. Immunohistochemistry of paraffin-embedded rat kidney using CHRFAM7A antibody. Immunohistochemistry of paraffin-embedded human prostate using CHRFAM7A antibody. Immunohistochemistry of paraffin-embedded human stomach using CHRFAM7A antibody. Immunohistochemistry of paraffin-embedded mouse brain using CHRFAM7A antibody. Immunohistochemistry of paraffin-embedded mouse stomach using CHRFAM7A antibody.
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |