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PAB35985 SART1 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35985
  • Application:    WB,IP,ELISA,IHC
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35985 SART1 Polyclonal Antibody

320.00元

Catalog : PAB35985
Application : WB,IP,ELISA,IHC
Reactivity : Human,Mouse,Rat

 

Product Information

 

Product name

SART1 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IP,ELISA,IHC

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human SART1

Calculated molecular weight

90kDa

Observed molecular weight 

120kDa

Swiss Prot

O43290

Gene ID (NCBI)

9092

Alternative Names

Ara1;HAF;HOMS1;SART1259;SNRNP110;Snu66;Ara1;HOMS1;SART1259;SNRNP110;Snu66


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IP

1:20 - 1:50

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using SART1 antibody.


Immunoprecipitation analysis of 150ug extracts of Jurkat cells using 3ug SART1 antibody.

Background


This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.. 


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.