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PAB35870 ABCC2 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35870
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human

库存 800 件

PAB35870 ABCC2 Polyclonal Antibody

320.00元

Catalog : PAB35870
Application : WB,ELISA,IHC
Reactivity : Human
Product Information


Product name

ABCC2 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human ABCC2

Calculated molecular weight

174kDa

Observed molecular weight 

344kDa

Swiss Prot

Q92887

Gene ID (NCBI)

1244

Alternative Names

ABC30;CMOAT;cMRP;DJS;MRP2


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

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Western blot analysis of extracts of various cell lines, using ABCC2 antibody.


Background

   

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. 

                                                                                              

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.