ABCC2 Polyclonal Antibody
Lyophilized or Liquid
Recombinant protein of human ABCC2
Calculated molecular weight
Observed molecular weight
Gene ID (NCBI)
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1:500 - 1:2000
1:50 - 1:500
Western blot analysis of extracts of various cell lines, using ABCC2 antibody.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.