欢迎来到Bioswamp武汉贝茵莱生物科技有限公司   注册   登录

PAB35986 GNE Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35986
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35986 GNE Polyclonal Antibody

320.00元

Catalog : PAB35986
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

GNE Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human GNE

Calculated molecular weight

66kDa/71kDa/78kDa/79kDa/83kDa

Observed molecular weight 

120kDa

Swiss Prot

Q9Y223

Gene ID (NCBI)

10020

Alternative Names

DMRV;GLCNE;IBM2;NM;Uae1


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:100

  image.png

Western blot analysis of extracts of various cell lines, using GNE antibody.         

image.png  image.png  image.png                   

Immunohistochemistry of paraffin-embedded mouse brain using GNE antibody.

Immunohistochemistry of paraffin-embedded rat brain using GNE antibody.

Immunohistochemistry of paraffin-embedded human colon using GNE antibody.

   image.png                       image.png

Immunohistochemistry of paraffin-embedded human esophagus using GNE antibody.


Immunohistochemistry of paraffin-embedded human stomach using GNE antibody.

 

Background


The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.  


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.