GNE Polyclonal Antibody
Lyophilized or Liquid
Recombinant protein of human GNE
Calculated molecular weight
Observed molecular weight
Gene ID (NCBI)
1:500 - 1:2000
1:50 - 1:100
Western blot analysis of extracts of various cell lines, using GNE antibody.
Immunohistochemistry of paraffin-embedded mouse brain using GNE antibody.
Immunohistochemistry of paraffin-embedded rat brain using GNE antibody.
Immunohistochemistry of paraffin-embedded human colon using GNE antibody.
Immunohistochemistry of paraffin-embedded human esophagus using GNE antibody.
Immunohistochemistry of paraffin-embedded human stomach using GNE antibody.
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.