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PAB35868 CTSC Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35868
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35868 CTSC Polyclonal Antibody

320.00元

Catalog : PAB35868
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information


Product name

CTSC Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human CTSC

Calculated molecular weight

15kDa/51kDa

Observed molecular weight 

70kDa

Swiss Prot

P53634

Gene ID (NCBI)

1075

Alternative Names

CPPI;DPP-I;DPP1;DPPI;HMS;JP;JPD;PALS;PDON1;PLS


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:100

 

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Western blot analysis of extracts of various cell lines, using CTSC antibody.

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Immunohistochemistry of paraffin-embedded human stomach using CTSC antibody.


Immunohistochemistry of paraffin-embedded rat kidney using CTSC antibody.


Background

   

This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.  

                                                                                              

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.