欢迎来到Bioswamp武汉贝茵莱生物科技有限公司   注册   登录

PAB35996 BCCIP Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35996
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 800 件

PAB35996 BCCIP Polyclonal Antibody

320.00元

Catalog : PAB35996
Application : WB,IHC,ELISA
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

BCCIP Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human BCCIP

Calculated molecular weight

33kDa/35kDa/36kDa

Observed molecular weight 

50kDa

Swiss Prot

Q9P287

Gene ID (NCBI)

56647

Alternative Names

TOK-1;TOK1


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:100 - 1:200

image.png   image.png                           

Western blot analysis of extracts of various cell lines, using BCCIP antibody.


Immunohistochemistry of paraffin-embedded human gastric cancer using BCCIP antibody.

 

image.png               image.png                   

Immunohistochemistry of paraffin-embedded human lung cancer using BCCIP antibody.


Immunohistochemistry of paraffin-embedded human stomach using BCCIP antibody.

     

Background


This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. 

 

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.