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PAB36240 RGS14 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB36240
  • Application:    WB,ELISA,IHC
  • Reactivity:    Human,Mouse

库存 800 件

PAB36240 RGS14 Polyclonal Antibody

320.00元

Catalog : PAB36240
Application : WB,ELISA,IHC
Reactivity : Human,Mouse
Product Information

 

Product name

RGS14 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,ELISA,IHC

Species reactivity

Human,Mouse

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human RGS14

Calculated molecular weight

21kDa/36kDa/44kDa/61kDa

Observed molecular weight 

54kDa

Swiss Prot

O43566

Gene ID (NCBI)

10636

Alternative Names

regulator of G-protein signaling 14


Application Notes



The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:500

           blob.png

Western blot analysis of extracts of various cell lines, using RGS14 antibody.


Background


This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.   


Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.