RGS14 Polyclonal Antibody
Lyophilized or Liquid
Recombinant protein of human RGS14
Calculated molecular weight
Observed molecular weight
Gene ID (NCBI)
regulator of G-protein signaling 14
1:500 - 1:2000
1:50 - 1:500
Western blot analysis of extracts of various cell lines, using RGS14 antibody.
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.